Categoria:
Seminário
Onde:
Híbrido
Local:
Sala 2.17D Departamento Química
Descrição:
Abstract:
Glycans play a crucial role in shaping adaptive immune responses. The recognition of glycans by glycan-binding receptors, such as the C-type lectins (CLRs), has illustrated their potent immune modulatory role and has implicated glycans not only in infectious diseases, but also revealed their extraordinary properties in tumor progression. We study how the “sugar blue print” is decoded by the immune system and how aberrant glycans orchestrate immune evasion during cancer. We have a particular focus on the dendritic cell-expressed CLR MGL (CLEC10A, CD301), which recognizes terminal N-acetylgalactosamine residues, such as the tumor-specific Tn antigen.... Therefore, in our latest studies we... Together our results emphasize that the impact of tumor-associated glycans on MGL signaling and anti-tumor immunity has a higher level of complexity than originally thought.
Ligação:
https://ucibio.pt/training/guestseminarsucibio-sandra-van-vliet
